Red-COLA1: a human fibroblast reporter cell line for type I collagen transcription
نویسندگان
چکیده
منابع مشابه
Inhibition of human scleral fibroblast cell attachment to collagen type I by TGFBIp.
PURPOSE Transforming growth factor beta-induced protein (TGFBIp; 68 kDa) is a secreted extracellular matrix (ECM) protein that has been demonstrated to regulate cell attachment in a variety of cell types. The sclera synthesizes and secretes TGFBIp, which may function to facilitate scleral ECM remodeling events associated with myopia development. Here the authors report that human scleral fibrob...
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A type I collagen reporter gene construct, designed to facilitate detailed analysis of the consequences of introduced structural and regulatory mutations on collagen biosynthesis and participation in the extracellular matrix, was produced by sitedirected mutagenesis of the mouse COLIAI gene. The reporter construct, pWTCI-Ile822, carried a single base change which converted the codon for amino a...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-75683-5